HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(Pyrimidin-4-yl)nicotinic acid dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl 2-(pyrimidin-4-yl)nicotinate | HCID 86680858 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-(Pyrimidin-4-yl)nicotinic acid dihydrochloride | HCID 86680856 | — |
Reaction Steps
A mixture of methyl 2-(pyrimidin-4-yl)nicotinate (0.19 g), acetic acid (1.0 mL) and 6 N hydrochloric acid (5 mL) was heated under reflux for 5 hr. The solvent was evaporated under reduced pressure to give the title compound (0.26 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09440990B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-6847e89e4e15488cb1fd19891d10ea2d |
| Source note | uspto-grants-2016_09 |