反应详情

Hydrazine (35% by weight in water, 0.67 mL, 7.2 mmol) and 10% Pd/C (38 mg, 0.03 mmol) are added to a solution of 1-isopropyl-4-(4-nitrophenyl)piperidine (180 mg, 0.72 mmol) in EtOH (10 mL) and the mixture is heated at reflux for 3 h. After cooling, the mixture is filtered through celite and the solvent evaporated. The residue is redissolved in DCM (25 mL), dried over MgSO4 and the solvent evaporated to afford the desired compound as a pale yellow solid (113 mg, 0.52 mmol) which was used without further purification.

1. temperaturethe mixture is heated
2. temperatureat reflux for 3 h
3. temperatureAfter cooling
4. filtrationthe mixture is filtered through celite
5. customthe solvent evaporated
6. dissolutionThe residue is redissolved in DCM (25 mL)
7. dry with materialdried over MgSO4
8. customthe solvent evaporated