HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-aminobenzoate → 4-(5-Bromo-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamino)-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-aminobenzoate | HCID 12082 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 5,8-Dibromo-(1,2,4)triazolo(1,5-a)pyrazine | HCID 49758022 | — |
| Reactant | 4-{8-[4-(4-Methyl-piperazin-1-yl)-phenylamino]-[1,2,4]triazolo[1,5-a]pyrazin-5-yl}-thiophene-2-carboxylic acid amide | HCID 57589928 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 4-(5-Bromo-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamino)-benzoic acid methyl ester | HCID 57590027 | — |
Reaction Steps
This compound may be prepared using methods as described for Compound 6, step 1 using 5,8-dibromo-[1,2,4]triazolo[1,5-a]pyrazine (250 mg, 0.90 mmol), 4-aminobenzoic methyl ester (163 mg, 1.08 mmol) and N-ethyldiisopropyl-amine (0.19 mL, 1.08 mmol) in 2-propanol (2.5 mL). The title compound is obtained after trituration with 2-propanol as a brown solid (148 mg, 47%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07915256B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-659f8acfac34400e8e47436d8c5e80b0 |
| Source note | uspto-grants-2011_03 |