(5-Bromo-[1,2,4]triazolo[1,5-a]pyrazin-8-yl)-[4-(4-isopropylpiperazin-1-yl)-3-trifluoromethylphenyl]amine → [4-(4-Isopropylpiperazin-1-yl)-3-trifluoromethylphenyl]-[5-(1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-8-yl]amine

HRID 606003Notes

Reaction equation

HRID 606003 reaction equation
C1(CN2CCN(C3[CH:16]=[CH:15][C:14]([NH:17][C:18]4[C:19]5[N:20]([N:29]=[CH:30][N:31]=5)[C:21]([C:24]5[CH:25]=[N:26][NH:27][CH:28]=5)=[CH:22][N:23]=4)=CC=3)CC2)CC1.BrC1N2N=CN=C2C(NC2C=C[C:46]([N:49]3[CH2:54][CH2:53][N:52]([CH:55]([CH3:57])[CH3:56])[CH2:51][CH2:50]3)=[C:45]([C:58]([F:61])([F:60])[F:59])[CH:44]=2)=NC=1>>[CH:55]([N:52]1[CH2:53][CH2:54][N:49]([C:46]2[CH:16]=[CH:15][C:14]([NH:17][C:18]3[C:19]4[N:20]([N:29]=[CH:30][N:31]=4)[C:21]([C:24]4[CH:25]=[N:26][NH:27][CH:28]=4)=[CH:22][N:23]=3)=[CH:44][C:45]=2[C:58]([F:61])([F:60])[F:59])[CH2:50][CH2:51]1)([CH3:57])[CH3:56]

Participants

3

Reactant 2

HCID 86619667(5-Bromo-[1,2,4]triazolo[1,5-a]pyrazin-8-yl)-[4-(4-isopropylpiperazin-1-yl)-3-trifluoromethylphenyl]amineHCID 135900377{4-[4-(Cyclopropylmethyl)piperazin-1-yl]phenyl}-[5-(1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-8-yl]amine

Product 1

HCID 135979631[4-(4-Isopropylpiperazin-1-yl)-3-trifluoromethylphenyl]-[5-(1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-8-yl]amine

Procedure

This compound may be prepared using methods as described for Compound 46, using (5-bromo-[1,2,4]triazolo[1,5-a]pyrazin-8-yl)-[4-(4-isopropylpiperazin-1-yl)-3-trifluoromethylphenyl]amine. LCMS: Rt=0.99 (95%), m/z (ESI) 472 (M+H)+.

Workup

  1. customThis compound may be prepared

Sources & evidence

ORD record
ord-ada7c0476ba240e586dd4f75ea8abaa3
Source dataset
uspto-grants-2011_03
Patent number
US07915256B2

Reaction notes

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