HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 606024Generated: October 31, 2026
Water → Diethyl {[(1-ethyl-1H-pyrazol-5-yl)amino]methylene}malonate
https://huagongshe.com/reaction/606024
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| Reactant | 1-Ethyl-1H-pyrazol-5-amine | HCID 337310 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Diethyl {[(1-ethyl-1H-pyrazol-5-yl)amino]methylene}malonate | HCID 12845080 | — |
Reaction Steps
A mixture of 5-amino-1-ethylpyrazole (1 gm, 0.0089 mole) and diethylethoxymethylenemalonate (1.9 ml, 0.0089 mole) was stirred at 120° C. for about 1 hour. The reaction mixture was poured into water and extraction was done with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and concentrated in vacuo to give yellow oil. Yield: 2.5 g. m/z: (M++1) 282.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07915286B2 |
|---|
| Source dataset | uspto-grants-2011_03 |
|---|
| ORD ID | ord-7589d9786b3a440296cbabbe81a0757c |
|---|
| Source note | uspto-grants-2011_03 |
|---|
