Water → HCID 66733147, compound

HRID 606027Notes

Reaction equation

HRID 606027 reaction equation
[CH:1]1([NH:4][C:5]2[C:10]([C:11]([O:13]CC)=[O:12])=[CH:9][N:8]=[C:7]3[N:16]([CH2:19][CH3:20])[N:17]=[CH:18][C:6]=23)[CH2:3][CH2:2]1.[OH-].[Na+].O>C(O)C>[CH:1]1([NH:4][C:5]2[C:10]([C:11]([OH:13])=[O:12])=[CH:9][N:8]=[C:7]3[N:16]([CH2:19][CH3:20])[N:17]=[CH:18][C:6]=23)[CH2:2][CH2:3]1

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 10378644HCID 10378644, compound

Product 1

HCID 66733147HCID 66733147, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of ethyl 4-cyclopropylamino-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate (1 g, 0.0036 mole) in ethanol, sodium hydroxide solution (440 mg in 2 ml water) was added. The reaction mixture was stirred for about 14 hours at ambient temperature. Water was added and the reaction mixture was extracted with ethyl acetate. Aqueous layer was acidified by using hydrochloric acid (2N) to pH of about 4-5. White solid, which was obtained, was filtered and dried in vacuo.

Workup

  1. extractionthe reaction mixture was extracted with ethyl acetate
  2. customWhite solid, which was obtained
  3. filtrationwas filtered
  4. customdried in vacuo

Sources & evidence

ORD record
ord-bf59faeffee6426485db0a52bfda0d29
Source dataset
uspto-grants-2011_03
Patent number
US07915286B2

Reaction notes

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