Citric Acid → HCID 86636866, compound

Participants

Reaction Steps

Toluene was cooled at −19 to −20° C. and vitride (0.50 ml, 0.0034 mole) was added. After about 10 minutes, 4-(cyclopropylamino)-1-ethyl-N-methoxy-N-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxamide (500 mg, 0.0017 mole) was added and the reaction mixture was stirred for about 4 hours. Citric acid (10%) solution was added dropwise to quench the reaction and the reaction mixture was extracted with ethyl acetate. The organic layer was washed with brine and dried over anhydrous sodium sulfate and concentrated in vacuo to give an oily compound. Yield: 300 mg. m/z: (M++1) 231.1.

Provenance & Evidence