反应详情

The methods described in Part H of Example 10 were used to treat 4-chloro-2-(ethoxymethyl)-1-[2-(3-methyl-1-oxa-2,4-diazaspiro[4,4]non-2-en-4-yl)ethyl]-1H-imidazo[4,5-c]quinoline (770 mg, 1.80 mmol) with a solution of 7 M ammonia in methanol (20 mL) and isolate and purify the final product to provide 700 mg of 2-(ethoxymethyl)-1-[2-(3-methyl-1-oxa-2,4-diazaspiro[4,4]non-2-en-4-yl)ethyl]-1H-imidazo[4,5-c]quinolin-4-amine as white needles, mp 211-213° C.

1. customisolate
2. custompurify the final product