1-{[3-(4-Fluorophenyl)isoxazol-5-yl]methyl}-N,N-bis(4-methoxybenzyl)-6,7-dimethyl-2-propyl-1H-imidazo[4,5-c]pyridin-4-amine → 1-{[3-(4-fluorophenyl)isoxazol-5-yl]methyl}-6,7-dimethyl-2-propyl-1H-imidazo[4,5-c]pyridin-4-amine

Participants

Reaction Steps

Under a nitrogen atmosphere, a solution of 1-{[3-(4-fluorophenyl)isoxazol-5-yl]methyl}-N,N-bis(4-methoxybenzyl)-6,7-dimethyl-2-propyl-1H-imidazo[4,5-c]pyridin-4-amine (2.62 g, 4.23 mmol) in trifluoroacetic acid (25 mL) was stirred at room temperature for 2.7 days. The solution was then worked-up and the product isolated and purified as described in Part B of Example 21 to provide 0.549 g of 1-{[3-(4-fluorophenyl)isoxazol-5-yl]methyl}-6,7-dimethyl-2-propyl-1H-imidazo[4,5-c]pyridin-4-amine as a white powder, mp 227.0-229.0° C.

Provenance & Evidence