4-Toluenesulfonyl chloride → HCID 59026673, compound

Participants

Reaction Steps

The methods described in Part I of Example 35 were used to treat 2-propyl-1-[(5-pyridin-3-ylisoxazol-3-yl)methyl]-1H-imidazo[4,5-c]quinoline (0.920 g, 3.00 mmol) with mCPBA (0.808 g of 77% pure material, 3.6 mmol) followed by p-toluenesulfonyl chloride (0.629 g, 3.30 mmol) and concentrated ammonium hydroxide (15 mL) and purify the final product to provide 0.46 g of 2-propyl-1-[(5-pyridin-3-ylisoxazol-3-yl)methyl]-1H-imidazo[4,5-c]quinolin-4-amine as a tan crystalline solid, mp 206-207° C.

Provenance & Evidence