4-Toluenesulfonyl chloride → HCID 59026670, compound

Participants

Reaction Steps

The methods described in Part I of Example 35 were used to treat 2-(ethoxymethyl)-1-[(5-phenylisoxazol-3-yl)methyl]-1H-imidazo[4,5-c]quinoline (0.650 g, 1.69 mmol) with mCPBA (0.455 g of 77% pure material, 2.0 mmol) followed by p-toluenesulfonyl chloride (0.355 g, 1.86 mmol) and concentrated ammonium hydroxide (15 mL) and purify the final product to provide 0.38 g of 2-(ethoxymethyl)-1-[(5-phenylisoxazol-3-yl)methyl]-1H-imidazo[4,5-c]quinolin-4-amine as a tan crystalline solid, mp 221-223° C.

Provenance & Evidence