HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 5-(Furan-2-yl)isoxazol-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | P,P-Diphenylphosphinic azide | HCID 199401 | — |
| Reactant | 5-(2-Furyl)isoxazole-3-carboxylic acid | HCID 1090982 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 5-(Furan-2-yl)isoxazol-3-amine | HCID 13230259 | 40% |
Reaction Steps
To a solution of 2.0 g of 5-furan-2-yl-isoxazole-3-carboxylic acid and 6.2 mL of TEA in benzene was added 3.61 mL of DPPA at room temperature. After refluxing for 1.5 hrs, 30 mL of distilled water was added and then the resulting solution was refluxed for an additional 30 min. The reaction solution was concentrated under reduced pressure, and the concentrate was purified by column chromatography on silica gel to obtain 0.6 g of 5-furan-2-yl-isoxazol-3-ylamine (Yield: 40%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07915297B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-4ebb5004b63c4d4eaca013a6f286976e |
| Source note | uspto-grants-2011_03 |