HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → N-(5-furan-2-yl-isoxazol-3-yl)-3-pyridin-2-yl-acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 3-(2-Pyridyl)acrylic acid | HCID 247824 | — |
| Reactant | 5-(Furan-2-yl)isoxazol-3-amine | HCID 13230259 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-(5-furan-2-yl-isoxazol-3-yl)-3-pyridin-2-yl-acrylamide | HCID 67047568 | 36% |
Reaction Steps
To a solution of 6 mg of 3-pyridin-2-yl-acrylic acid and 6 mg of 5-furan-2-yl-isoxazol-3-ylamine in DMF were added 8 mg of HOBt, 9 mg of EDC and 0.014 mL of TEA. The reaction solution was stirred for 18 hrs at room temperature, followed by concentration under reduced pressure. The concentrate was purified by preparative HPLC to provide 4 mg of N-(5-furan-2-yl-isoxazol-3-yl)-3-pyridin-2-yl-acrylamide. (Yield: 36%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07915297B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-b668bced9f59491b94c4f4a2666273b0 |
| Source note | uspto-grants-2011_03 |