反应详情

To a solution of 1.41 g of (5-furan-2-yl-isoxazol-3-yl)-methanol and 1.77 mL of TEA in 45 mL of methylene chloride was slowly added 0.73 mL of methanesulfonyl chloride at 0° C. After stirring for 1 hr, the reaction solution was washed with water and 1N HCl, dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to provide 10.0 g of methanesulfonic acid 5-furan-2-yl-isoxazol-3-ylmethyl ester. This concentrate was used for the next step without further purification.

1. customat 0° C
2. washthe reaction solution was washed with water and 1N HCl
3. dry with materialdried over anhydrous sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated in vacuo