HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → N-((5-(furan-2-yl)isoxazol-3-yl)methyl)-2-phenylacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | Phenylacetic Acid | HCID 999 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 5-(2-Furanyl)-3-isoxazolemethanamine | HCID 7060533 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-((5-(furan-2-yl)isoxazol-3-yl)methyl)-2-phenylacetamide | HCID 45510465 | 46.5% |
Reaction Steps
To a solution of 7 mg of phenylacetic acid and 5 mg of C-(5-furan-2-yl-isoxazol-3-yl)-methylamine in DMF were added 8 mg of HOBt, 9 mg of EDC and 0.02 mL of TEA. After stirring at room temperature for 18 hrs, the reaction mixture was concentrated in vacuo. The concentrate was purified by preparative HPLC to produce 4 mg of the isoxazole derivative (Yield: 35%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07915297B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-cbcdbb729c5d4f219f306fd27cd42aa3 |
| Source note | uspto-grants-2011_03 |