HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1'-Carbonyldiimidazole → imidazole-1-carboxylic Acid 5-furan-2-yl-isoxazol-3-ylmethyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | (5-(Furan-2-yl)-1,2-oxazol-3-yl)methanol | HCID 7164591 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | imidazole-1-carboxylic Acid 5-furan-2-yl-isoxazol-3-ylmethyl Ester | HCID 57696236 | 90% |
Reaction Steps
To a solution 200 mg of (5-furan-2-yl-isoxazol-3-yl)-methanol in 6 mL of methylene chloride was added 216 mg of CDI. After stirring at room temperature for 4 hrs, the reaction mixture was concentrated under reduced pressure. The concentrate was purified by column chromatography to afford 282 mg of the title compound. (Yield: 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07915297B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-0f2ac3c1622b43d79fba1d3ec310e2c7 |
| Source note | uspto-grants-2011_03 |