3,5-Difluorophenol → 1,3-Difluoro-5-(prop-2-yn-1-yloxy)benzene

HRID 606345Notes

Reaction equation

HRID 606345 reaction equation
F[C:2]1([O:9][C:10]#[C:11][CH3:12])[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][CH2:3]1.[F:13]C1C=C(O)C=C(F)C=1>>[F:8][C:6]1[CH:7]=[C:2]([O:9][CH2:10][C:11]#[CH:12])[CH:3]=[C:4]([F:13])[CH:5]=1

Participants

3

Reactant 2

HCID 759283,5-DifluorophenolHCID 670477642,4-Difluoro-2-propynyloxybenzene

Product 1

HCID 224828501,3-Difluoro-5-(prop-2-yn-1-yloxy)benzeneYield 67%

Procedure

This compound was prepared analogously to 2,4-difluoro-2-propynyloxybenzene but using 3,5-difluoro-phenol (14 g, 107 mmol) to give 1,3-difluoro-5-prop-2-ynyloxy-benzene 12 g (67%).

Sources & evidence

ORD record
ord-d98b1a2db2f340cdbd0576ce423250b7
Source dataset
uspto-grants-2011_03
Patent number
US07915295B2

Reaction notes

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