Ethyl 5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxylate → 5-methyl-4-oxo-N-[(3-{[4-(1H-1,2,4-triazol-3-ylthio)butyl]oxy}phenyl)methyl]-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxamide

Participants

Reaction Steps

By a method similar to that in Example 15, and using, instead of ethyl 6-cyano-4-oxo-3,4-dihydroquinazoline-2-carboxylate, ethyl 5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxylate obtained according to the method described in 034054656 and using, instead of 1-{3-[(3-{(1 (triphenylmethyl)-1H-1,2,4-triazol-3-yl]thiopropyl)oxy}phenyl}methaneamine, 1-{3-[(4-{[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]thio}butyl)oxy]phenyl}methanamine obtained in Reference Example 11, the title compound was obtained as a pales yellow powder (232 mg, 48%).

Provenance & Evidence