Trifluoroacetic acid → HCID 178509494, compound

Participants

Reaction Steps

A solution of 6-cyano-4-oxo-N-({3-[({[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]carbonyl}amino)methyl]phenyl}methyl)-3,4-dihydroquinazoline-2-carboxamide (420 mg, 0.626 mmol), triethylsilane (0.105 mL, 0.657 mmol) and trifluoroacetic acid (3 mL) in dichloromethane (10 mL) was stirred at room temperature for 30 min. The reaction mixture was concentrated under reduced pressure, and the residue was crystallized from IPE. The obtained powder was suspended in ethanol, and the suspension was stirred under heating for 2 hr to give the title compound as a white powder (113 mg, 42%).

Provenance & Evidence