HRID606396

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：N#Cc1ccc2nc(C(=O)NCc3cccc(NC(=O)CCc4ncn(C(c5ccccc5)(c5ccccc5)c5ccccc5)n4)c3)[nH]c(=O)c2c1

HCID136380964

未命名化合物

结构：N#Cc1ccc2nc(C(=O)NCc3cccc(NC(=O)c4ncn(C(c5ccccc5)(c5ccccc5)c5ccccc5)n4)c3)[nH]c(=O)c2c1

HCID136380968

未命名化合物

PRODUCTS

生成物

结构：N#Cc1ccc2nc(C(=O)NCc3cccc(NC(=O)c4nc[nH]n4)c3)[nH]c(=O)c2c1

HCID178509497

未命名化合物

PROCEDURE

实验过程

By a method similar to that in Step 2 of Example 32 and using, instead of 6-cyano-4-oxo-N-{[3-({3-[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]propanoyl}amino)phenyl]methyl}-3,4-dihydroquinazoline-2-carboxamide, 6-cyano-4-oxo-N-{[3-({[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]carbonyl}amino)phenyl]methyl}-3,4-dihydroquinazoline-2-carboxamide, the title compound was obtained as a white powder (355 mg, 95%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-79ab219e20f34d2098341870684db112
来源数据集: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07915267B2
来源说明: uspto-grants-2011_03

反应 SMILES

C(C1C=C2C(=CC=1)N=C(C(NCC1C=CC=C(NC(=O)CCC3N=CN(C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)N=3)C=1)=O)NC2=O)#N.[C:53]([C:55]1[CH:56]=[C:57]2[C:62](=[CH:63][CH:64]=1)[N:61]=[C:60]([C:65]([NH:67][CH2:68][C:69]1[CH:74]=[CH:73][CH:72]=[C:71]([NH:75][C:76]([C:78]3[N:82]=[CH:81][N:80](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[N:79]=3)=[O:77])[CH:70]=1)=[O:66])[NH:59][C:58]2=[O:102])#[N:54]>>[C:53]([C:55]1[CH:56]=[C:57]2[C:62](=[CH:63][CH:64]=1)[N:61]=[C:60]([C:65]([NH:67][CH2:68][C:69]1[CH:74]=[CH:73][CH:72]=[C:71]([NH:75][C:76]([C:78]3[N:82]=[CH:81][NH:80][N:79]=3)=[O:77])[CH:70]=1)=[O:66])[NH:59][C:58]2=[O:102])#[N:54]