5-methyl-4-oxo-N-{[3-({[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]carbonyl}amino)phenyl]methyl}-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxamide → HCID 178431870, compound

HRID 606398Notes

Reaction equation

HRID 606398 reaction equation
C(C1C=C2C(=CC=1)N=C(C(NCC1C=CC=C(NC(=O)CCC3N=CN(C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)N=3)C=1)=O)NC2=O)#N.[CH3:53][C:54]1[C:62]2[C:61](=[O:63])[NH:60][C:59]([C:64]([NH:66][CH2:67][C:68]3[CH:73]=[CH:72][CH:71]=[C:70]([NH:74][C:75]([C:77]4[N:81]=[CH:80][N:79](C(C5C=CC=CC=5)(C5C=CC=CC=5)C5C=CC=CC=5)[N:78]=4)=[O:76])[CH:69]=3)=[O:65])=[N:58][C:57]=2[S:56][CH:55]=1>>[CH3:53][C:54]1[C:62]2[C:61](=[O:63])[NH:60][C:59]([C:64]([NH:66][CH2:67][C:68]3[CH:73]=[CH:72][CH:71]=[C:70]([NH:74][C:75]([C:77]4[N:81]=[CH:80][NH:79][N:78]=4)=[O:76])[CH:69]=3)=[O:65])=[N:58][C:57]=2[S:56][CH:55]=1

Participants

3

Reactant 2

HCID 667691025-methyl-4-oxo-N-{[3-({[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]carbonyl}amino)phenyl]methyl}-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxamideHCID 1363809646-cyano-4-oxo-N-{[3-({3-[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]propanoyl}amino)phenyl]methyl}-3,4-dihydroquinazoline-2-carboxamide

Product 1

HCID 178431870HCID 178431870, compound

Procedure

By a method similar to that in Step 2 of Example 32 and using, instead of 6-cyano-4-oxo-N-{[3-({3-[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]propanoyl}amino)phenyl]methyl}-3,4-dihydroquinazoline-2-carboxamide, 5-methyl-4-oxo-N-{[3-({[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]carbonyl}amino)phenyl]methyl}-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxamide, the title compound was obtained as a white powder (339 mg, 99%).

Sources & evidence

ORD record
ord-b575d61732604dd492a20f6a4341b1d1
Source dataset
uspto-grants-2011_03
Patent number
US07915267B2

Reaction notes

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