1-Hydroxybenzotriazole → HCID 178520677, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 4-{[3-({[(4-oxo-3,4-dihydroquinazolin-2-yl)carbonyl]amino}methyl)phenyl]oxy}butanoic acid obtained in Reference Example 44 (100 mg, 0.262 mmol), 1H-1,2,4-triazol-3-amine (26.4 mg, 0.314 mmol), 1-[3-(dimethylamino)propyl]-3-ethyl-carbodiimide hydrochloride (60.3 mg, 0.314 mmol) and 1-hydroxybenzotriazole (42.5 mg, 0.314 mmol) in DMF (5 mL) was stirred at 40° C. for 5 hr. Water was added to the reaction mixture, and the resulting solid was collected by filtration, washed with water and IPE, and dried to give the title compound as a white powder (95.0 mg, 73%).

Provenance & Evidence