ethyl 4-{[({4-oxo-2-[({[2-({3-[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]propyl}oxy)pyridin-4-yl]methyl}amino)carbonyl]-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl}methyl)oxy]methyl}benzoate → HCID 178468934, compound

HRID 606400Notes

Reaction equation

HRID 606400 reaction equation
C(C1C=C2C(=CC=1)N=C(C(NCC1C=CC=C(NC(=O)CCC3N=CN(C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)N=3)C=1)=O)NC2=O)#N.[O:53]=[C:54]1[NH:59][C:58]([C:60]([NH:62][CH2:63][C:64]2[CH:69]=[CH:68][N:67]=[C:66]([O:70][CH2:71][CH2:72][CH2:73][C:74]3[N:78]=[CH:77][N:76](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[N:75]=3)[CH:65]=2)=[O:61])=[N:57][C:56]2[S:98][CH:99]=[C:100]([CH2:101][O:102][CH2:103][C:104]3[CH:114]=[CH:113][C:107]([C:108]([O:110][CH2:111][CH3:112])=[O:109])=[CH:106][CH:105]=3)[C:55]1=2>>[O:53]=[C:54]1[NH:59][C:58]([C:60]([NH:62][CH2:63][C:64]2[CH:69]=[CH:68][N:67]=[C:66]([O:70][CH2:71][CH2:72][CH2:73][C:74]3[N:78]=[CH:77][NH:76][N:75]=3)[CH:65]=2)=[O:61])=[N:57][C:56]2[S:98][CH:99]=[C:100]([CH2:101][O:102][CH2:103][C:104]3[CH:114]=[CH:113][C:107]([C:108]([O:110][CH2:111][CH3:112])=[O:109])=[CH:106][CH:105]=3)[C:55]1=2

Participants

3

Reactant 2

HCID 66769032ethyl 4-{[({4-oxo-2-[({[2-({3-[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]propyl}oxy)pyridin-4-yl]methyl}amino)carbonyl]-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl}methyl)oxy]methyl}benzoateHCID 1363809646-cyano-4-oxo-N-{[3-({3-[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]propanoyl}amino)phenyl]methyl}-3,4-dihydroquinazoline-2-carboxamide

Product 1

HCID 178468934HCID 178468934, compound

Procedure

By a method similar to that in Step 2 of Example 32 and using, instead of 6-cyano-4-oxo-N-{[3-({3-[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]propanoyl}amino)phenyl]methyl}-3,4-dihydroquinazoline-2-carboxamide, ethyl 4-{[({4-oxo-2-[({[2-({3-[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]propyl}oxy)pyridin-4-yl]methyl}amino)carbonyl]-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl}methyl)oxy]methyl}benzoate, the title compound was obtained as a white powder (20.0 mg, 93%).

Sources & evidence

ORD record
ord-def82bd51ca447e0917dcb511925c279
Source dataset
uspto-grants-2011_03
Patent number
US07915267B2

Reaction notes

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