反应详情

To a solution of 5,6-difluoro-4-oxo-N-({3-[(2-{[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]oxy}ethyl)oxy]phenyl}methyl)-3,4-dihydroquinazoline-2-carboxamide obtained in Step 1 (70 mg, 0.102 mmol) in dichloromethane (1 mL) were added trifluoroacetic acid (0.30 mL) and triethylsilane (0.020 mL, 0.123 mmol) at room temperature, and the mixture was stirred for 1 hr. The reaction mixture was concentrated under reduced pressure, and the residue was crystallized from diethyl ether to give the title compound as a pale-yellow powder (38 mg, 84%).

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. customthe residue was crystallized from diethyl ether