HCID 57708813, compound → HCID 178489864, compound

HRID 606417Notes

Reaction equation

HRID 606417 reaction equation
O=C1C2C(=CC=CC=2)N=C(C(OCC)=O)N1.[CH3:17][O:18][C:19]1[CH:20]=[C:21]([C:25]2[C:33]3[C:32](=[O:34])[NH:31][C:30]([C:35]([O:37]CC)=O)=[N:29][C:28]=3[S:27][CH:26]=2)[CH:22]=[CH:23][CH:24]=1.C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)N2C=NC(CCCOC3C=C(CN)C=CN=3)=N2)C=CC=CC=1.C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[N:83]2[CH:87]=[N:86][C:85]([O:88][CH2:89][CH2:90][O:91][C:92]3[CH:93]=[C:94]([CH2:98][NH2:99])[CH:95]=[CH:96][CH:97]=3)=[N:84]2)C=CC=CC=1>>[CH3:17][O:18][C:19]1[CH:20]=[C:21]([C:25]2[C:33]3[C:32](=[O:34])[NH:31][C:30]([C:35]([NH:99][CH2:98][C:94]4[CH:95]=[CH:96][CH:97]=[C:92]([O:91][CH2:90][CH2:89][O:88][C:85]5[N:86]=[CH:87][NH:83][N:84]=5)[CH:93]=4)=[O:37])=[N:29][C:28]=3[S:27][CH:26]=2)[CH:22]=[CH:23][CH:24]=1

Participants

5

Reactant 4

HCID 57708813HCID 57708813, compoundHCID 667687691-[2-({3-[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]propyl}oxy)pyridin-4-yl]methanamineHCID 667690991-{3-[(2-([1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]oxy)ethyl)oxy}phenyl]methanamineHCID 135437466Ethyl 4-oxo-3,4-dihydroquinazoline-2-carboxylate

Product 1

HCID 178489864HCID 178489864, compound

Procedure

By a method similar to that in Example 22, and using, instead of ethyl 4-oxo-3,4-dihydro-2-quinazolinecarboxylate, ethyl 5-(3-methoxyphenyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxylate obtained in Reference Example 74 and using, instead of 1-[2-({3-[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]propyl}oxy)pyridin-4-yl]methaneamine, 1-{3-[(2-{[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]oxy}ethyl)oxy]phenyl}methanamine obtained in Reference Example 32, the title compound was obtained as a white powder (117.5 mg, 50%).

Workup

  1. customobtained in Reference Example 74
  2. customobtained in Reference Example 32

Sources & evidence

ORD record
ord-00866587411c4dea9641835e5e9e060c
Source dataset
uspto-grants-2011_03
Patent number
US07915267B2

Reaction notes

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