Ethyl 5-[3-(ethoxycarbonyl)phenyl]-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxylate → HCID 178468823, compound

HRID 606425Notes

Reaction equation

HRID 606425 reaction equation
O=C1C2C(=CC=CC=2)N=C(C(OCC)=O)N1.[CH2:17]([O:19][C:20]([C:22]1[CH:23]=[C:24]([C:28]2[C:36]3[C:35](=[O:37])[NH:34][C:33]([C:38](OCC)=[O:39])=[N:32][C:31]=3[S:30][CH:29]=2)[CH:25]=[CH:26][CH:27]=1)=[O:21])[CH3:18].C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)N2C=NC(CCCOC3C=C(CN)C=CN=3)=N2)C=CC=CC=1.C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[N:86]2[CH:90]=[N:89][C:88]([O:91][CH2:92][CH2:93][O:94][C:95]3[CH:96]=[C:97]([CH2:101][NH2:102])[CH:98]=[CH:99][CH:100]=3)=[N:87]2)C=CC=CC=1>>[O:37]=[C:35]1[NH:34][C:33]([C:38](=[O:39])[NH:102][CH2:101][C:97]2[CH:98]=[CH:99][CH:100]=[C:95]([O:94][CH2:93][CH2:92][O:91][C:88]3[N:89]=[CH:90][NH:86][N:87]=3)[CH:96]=2)=[N:32][C:31]2[S:30][CH:29]=[C:28]([C:24]3[CH:23]=[C:22]([CH:27]=[CH:26][CH:25]=3)[C:20]([O:19][CH2:17][CH3:18])=[O:21])[C:36]1=2

Participants

5

Reactant 4

HCID 57708800Ethyl 5-[3-(ethoxycarbonyl)phenyl]-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxylateHCID 667687691-[2-({3-[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]propyl}oxy)pyridin-4-yl]methanamineHCID 667690991-{3-[(2-([1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]oxy)ethyl)oxy}phenyl]methanamineHCID 135437466Ethyl 4-oxo-3,4-dihydroquinazoline-2-carboxylate

Product 1

HCID 178468823HCID 178468823, compound

Procedure

By a method similar to that in Example 22, and using, instead of ethyl 4-oxo-3,4-dihydro-2-quinazolinecarboxylate, ethyl 5-[3-(ethoxycarbonyl)phenyl]-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxylate obtained in Reference Example 82 and using, instead of 1-[2-({3-[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]propyl}oxy)pyridin-4-yl]methaneamine, 1-{3-[(2-{[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]oxy}ethyl)oxy]phenyl}methanamine obtained in Reference Example 32, the title compound was obtained as a white powder (132.7 mg, 58%).

Workup

  1. customobtained in Reference Example 82
  2. customobtained in Reference Example 32

Sources & evidence

ORD record
ord-c85a7b71235a4cc98344eb67eb0ba0ce
Source dataset
uspto-grants-2011_03
Patent number
US07915267B2

Reaction notes

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