Ammonia → HCID 136054490, compound

Participants

Reaction Steps

A suspension of N-[(4′-{[2-(hydroxyamino)-3-methylbutyl]sulfonyl}biphenyl-3-yl)methyl]-4-oxo-3,4-dihydroquinazoline-2-carboxamide obtained in Reference Example 107 (0.050 g, 0.096 mmol) and N,N-diisopropylethylamine (0.017 mL, 0.096 mmol) in THF (10 mL) was added dropwise to a suspension of triphosgene (0.0094 g, 0.032 mmol) in THF (2 mL) at 0° C., and the mixture was stirred at room temperature for 2 hr. 28% Aqueous ammonia (0.065 mL, 0.960 mmol) was added thereto, and the mixture was stirred at room temperature for 2 hr. The reaction mixture was concentrated under reduced pressure, and the residue was crystallized from EtOH-water to give the title compound as a white powder (0.045 g, 83%).

Provenance & Evidence