Ethyl 5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxylate → 5-methyl-4-oxo-N-({3'-[(1H-1,2,4-triazol-3-yloxy)methyl]biphenyl-3-yl}methyl)-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxamide

Participants

Reaction Steps

By a method similar to that in Example 22, and using, instead of ethyl 4-oxo-3,4-dihydro-2-quinazolinecarboxylate, ethyl 5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxylate obtained according to the method described in U.S. Pat. No. 4,054,656 and using, instead of 1-[2-({3-[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]propyl}oxy)pyridin-4-yl]methaneamine, 1-(3′-{[(1-trityl-1H-1,2,4-triazol-3-yl)oxy]methyl}biphenyl-3-yl)methanamine obtained in Reference Example 135, the title compound was obtained as a white powder (4.7 mg, 2%).

Provenance & Evidence