反应详情

温度

80 °C

A suspension of ethyl (5-mercapto-1H-1,2,4-triazol-3-yl)acetate obtained in Reference Example 13 (2.00 g, 10.7 mmol) and Raney-nickel (5.00 g) in ethanol (20 mL) was stirred at 80° C. for 15 hr. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure. To a suspension of the residue in ethyl acetate was added activated carbon, and the mixture was filtered. the filtrate was concentrated under reduced pressure to give the title compound as a pale-green powder (900 mg, 54%).

1. filtrationThe catalyst was filtered off
2. concentrationthe filtrate was concentrated under reduced pressure
3. additionTo a suspension of the residue in ethyl acetate
4. additionwas added
5. filtrationthe mixture was filtered
6. concentrationthe filtrate was concentrated under reduced pressure