HCID 66768878, compound → 1-{3-[(2-([1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]oxy)ethyl)oxy}phenyl]methanamine

HRID 606463Notes

Reaction equation

HRID 606463 reaction equation
C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)N2C=NC(SCCOC3C=C(C#N)C=CN=3)=N2)C=CC=CC=1.[C:37]1([C:43]([C:67]2[CH:72]=[CH:71][CH:70]=[CH:69][CH:68]=2)([C:61]2[CH:66]=[CH:65][CH:64]=[CH:63][CH:62]=2)[N:44]2[CH:48]=[N:47][C:46]([O:49][CH2:50][CH2:51][O:52][C:53]3[CH:54]=[C:55]([CH:58]=[CH:59][CH:60]=3)[C:56]#[N:57])=[N:45]2)[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1>>[C:67]1([C:43]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)([C:61]2[CH:62]=[CH:63][CH:64]=[CH:65][CH:66]=2)[N:44]2[CH:48]=[N:47][C:46]([O:49][CH2:50][CH2:51][O:52][C:53]3[CH:54]=[C:55]([CH2:56][NH2:57])[CH:58]=[CH:59][CH:60]=3)=[N:45]2)[CH:72]=[CH:71][CH:70]=[CH:69][CH:68]=1

Participants

3

Reactant 2

HCID 66768878HCID 66768878, compoundHCID 66769059HCID 66769059, compound

Product 1

HCID 667690991-{3-[(2-([1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]oxy)ethyl)oxy}phenyl]methanamine

Procedure

By a method similar to that in Reference Example 20 and using, instead of 2-[(2-{[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]thio}ethyl)oxy]pyridine-4-carbonitrile, 3-[(2-{[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]oxy}ethyl)oxy]benzonitrile obtained in Reference Example 31, the title compound was obtained as a colorless oil (504 mg, 99%).

Workup

  1. customobtained in Reference Example 31

Sources & evidence

ORD record
ord-ea1e5df5c7524e948da151620492c8f0
Source dataset
uspto-grants-2011_03
Patent number
US07915267B2

Reaction notes

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