methyl 1-trityl-1H-1,2,4-triazole-3-carboxylate → 1-trityl-1H-[1,2,4]triazole-3-carboxylic acid

HRID 606465Notes

Reaction equation

HRID 606465 reaction equation
N1C=NC(CC(OCC)=O)=N1.[C:12]1([C:18]([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[N:19]2[CH:23]=[N:22][C:21]([C:24]([O:26]C)=[O:25])=[N:20]2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[C:34]1([C:18]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)([C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[N:19]2[CH:23]=[N:22][C:21]([C:24]([OH:26])=[O:25])=[N:20]2)[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1

Participants

3

Reactant 2

HCID 58739241methyl 1-trityl-1H-1,2,4-triazole-3-carboxylateHCID 178470784HCID 178470784, compound

Product 1

HCID 218918071-trityl-1H-[1,2,4]triazole-3-carboxylic acid

Procedure

By a method similar to that in Reference Example 15 and using, instead of ethyl 1H-1,2,4-triazol-3-ylacetate, methyl 1-(triphenylmethyl)-1H-1,2,4-triazole-3-carboxylate obtained in Reference Example 34, the title compound was obtained as a white powder (2.82 g, 98%).

Workup

  1. customobtained in Reference Example 34

Sources & evidence

ORD record
ord-8ab66273fab74f3ba7b007e6272eb07c
Source dataset
uspto-grants-2011_03
Patent number
US07915267B2

Reaction notes

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