tert-butyl N-((3-(aminomethyl)phenyl)methyl)carbamate → 1,1-Dimethylethyl {[3-({[(5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)carbonyl]amino}methyl)phenyl]methyl}carbamate

Participants

Reaction Steps

By a method similar to that in Reference Example 45, and using, instead of ethyl 6-cyano-4-oxo-3,4-dihydroquinazoline-2-carboxylate, ethyl 5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxylate obtained according to the method described in U.S. Pat. No. 4,054,656 and using, instead of 3-(aminomethyl)aniline, 1,1-dimethylethyl {[3-(aminomethyl)phenyl]methyl}carbamate, the title compound was obtained as a white powder (2.11 g, 82%).

Provenance & Evidence