Tetrahydrofuran → Ethyl {[4-amino-2-(aminocarbonyl)phenyl]amino}(oxo)acetate

Participants

Reaction Steps

To a solution of ethyl {[2-(aminocarbonyl)-4-nitrophenyl]amino}(oxo)acetate (2.292 g) in a mixed solvent of THF (100 mL)-ethanol (50 mL) was added 10% palladium carbon (405 mg), and the mixture was subjected to catalytic reduction under hydrogen atmosphere at room temperature for 8 hr. The catalyst was filtered off, and the filtrate was concentrated. The obtained crude crystals were washed with diisopropyl ether to give ethyl {[4-amino-2-(aminocarbonyl)phenyl]amino}(oxo)acetate (1.96 g, 96%).

Provenance & Evidence