反应详情

温度

90 °C

Methyl 4-amino-1-[2-({4-[(methyloxy)carbonyl]phenyl}oxy)ethyl]-1H-pyrazole-5-carboxylate (2.18 g, 6.83 mmol) and ethyl cyanoformate (811 mg, 8.18 mmol) were added to 1N hydrogen chloride-acetic acid (40 mL), and the mixture was stirred under heating at 90° C. for 4 hr. After the mixture was allowed to cool, diethyl ether was added, and the precipitated crude crystals were collected by filtration, and washed with diethyl ether to give the title compound (1.79 g).

1. temperatureto cool
2. customthe precipitated crude crystals
3. filtrationwere collected by filtration
4. washwashed with diethyl ether