Methanol → 4-oxo-N-[(3-piperazin-1-ylphenyl)methyl]-3,4-dihydroquinazoline-2-carboxamide dihydrochloride

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Reaction Steps

To a suspension of 1,1-dimethylethyl 4-[3-({[(4-oxo-3,4-dihydroquinazolin-2-yl)carbonyl]amino}methyl)phenyl]piperazine-1-carboxylate obtained in Reference Example 115 (2.40 g, 6.86 mmol) in ethyl acetate (10 mL)-THF (50 ml)-methanol (40 mL) was added 4N hydrogen chloride-ethyl acetate (10.4 mL), and the mixture was stirred at room temperature for 4 hr, and then at 50° C. for 2 hr. Diethyl ether (about 100 mL) was added to the reaction mixture, and the precipitated solid was collected by filtration to give the title compound as a white powder (2.18 g, 97%).

Provenance & Evidence