Hydrazine → Ethyl (5-oxo-2,5-dihydro-1H-pyrazol-3-yl)acetate

Participants

Reaction Conditions

Reaction Steps

To a solution of diethyl 3-oxopentanedioate (26.0 g, 129 mmol) in EtOH (250 mL) was added hydrazine (4.38 g, 129 mmol) at room temperature, and the mixture was stirred at 80° C. for 3 hr. The reaction mixture was concentrated under reduced pressure, and the residue was crystallized from diethyl ether-hexane to give the title compound as a white powder (9.79 g, 45%).

Provenance & Evidence