3-(2-Chloroethoxy)benzonitrile → 3-{3-[(5-phenyl-1H-1,2,4-triazol-3-yl)thio]propoxy}benzonitrile

HRID 606526Notes

Reaction equation

HRID 606526 reaction equation
ClCCOC1C=C(C=CC=1)C#N.Cl[CH2:14][CH2:15][CH2:16][O:17][C:18]1[CH:19]=[C:20]([CH:23]=[CH:24][CH:25]=1)[C:21]#[N:22].N1C=NC(S)=N1.[C:32]1([C:38]2[NH:42][N:41]=[C:40]([SH:43])[N:39]=2)[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[C:32]1([C:38]2[NH:42][N:41]=[C:40]([S:43][CH2:14][CH2:15][CH2:16][O:17][C:18]3[CH:19]=[C:20]([CH:23]=[CH:24][CH:25]=3)[C:21]#[N:22])[N:39]=2)[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1

Participants

5

Reactant 4

HCID 135691673-(2-Chloroethoxy)benzonitrileHCID 219940813-(3-Chloropropoxy)benzonitrileHCID 178527894HCID 178527894, compoundHCID 178527978HCID 178527978, compound

Product 1

HCID 577088993-{3-[(5-phenyl-1H-1,2,4-triazol-3-yl)thio]propoxy}benzonitrile

Procedure

By a method similar to that in Reference Example 2, and using, instead of 3-[(2-chloroethyl)oxy]benzonitrile, 3-[(3-chloropropyl)oxy]benzonitrile obtained in Reference Example 4 and using, instead of 1H-1,2,4-triazole-3-thiol, 5-phenyl-1H-1,2,4-triazole-3-thiol, the title compound was obtained as a white powder (1.01 g, 59%).

Workup

  1. customobtained in Reference Example 4

Sources & evidence

ORD record
ord-72a2e624c3664d64b10827d4847b1138
Source dataset
uspto-grants-2011_03
Patent number
US07915267B2

Reaction notes

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