HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 67068967, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | delta-Gluconolactone | HCID 7027 | — |
| Reactant | Bicyclo[2.2.1]hept-2-ene-1-carbonitrile | HCID 19737575 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | HCID 57027427 | HCID 57027427 | — |
| Product | HCID 67068967 | HCID 67068967 | 70% |
Reaction Steps
2 ml methanol was added to a 50 ml flask containing 1 g Glucolactone (Aldrich), the solid does not dissolve initially. By the addition of 0.74 g Norbornenyl-methylamine (prepared in lab by the reduction of norbornene carbonitrile with LiAlH4), it disappeared gradually within 20 minutes. The reaction proceeded overnight at room temperature. After the reaction, methanol was removed on a rotary evaporator, and the product was recrystalized from iPrOH/petroleum ether at −4° C. with a yield greater than 70%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07915318B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-4e2f793bc0284991a0cb55c1735977e6 |
| Source note | uspto-grants-2011_03 |