Ammonium formate → HCID 178524346, compound

Participants

Reaction Conditions

Reaction Steps

E-4-[2-(1-Methyl-1H-imidazol-2-yl)-vinyl]-benzoic acid methyl ester was hydrogenated using Pd/C (10% of substrate weight), ammonium formate (5 equivalents) in isopropanol heated by microwave irradiation (200 W) for 5 mins at 150° C. The solution was filtered through celite to remove the insoluble catalyst, diluted with water and freeze-dried to remove the excess of ammonium formate. The obtained solid was hydrolysed by 6N aqueous HCl solution heated by microwave irradiation (200 W) for 3 mins at 150° C. The solution was freeze dried to give to the hydrochloride salt of the title compound as a white powder m/z=217 in MS ES+, which was characterised by HPLC and MS.

Provenance & Evidence