反应详情

温度

4 °C

4-(2-Bromo-acetyl)-benzoic acid methyl ester (15.5 mmol) was dissolved in ethanol (120 ml) and acetic acid (4.8 ml). Sodium azide (31 mmol) was added and the reaction stirred at 4° C. overnight. The ethanol was removed and the mixture diluted with ethyl acetate (100 ml). The organic layer was washed with saturated sodium hydrogen carbonate (2'50 ml) and dried (MgSO4). The solvent was removed in vacuo to give a yellow solid, which was re-crystallized from ethanol to give the title compound as a pale yellow solid (2.6 g). IR 2117 cm−1

1. customThe ethanol was removed
2. additionthe mixture diluted with ethyl acetate (100 ml)
3. washThe organic layer was washed with saturated sodium hydrogen carbonate (2'50 ml) and
4. dry with materialdried (MgSO4)
5. customThe solvent was removed in vacuo
6. customto give a yellow solid, which
7. customwas re-crystallized from ethanol