HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → HCID 123427162, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | 3-(5-Amino-3-tert-butyl-pyrazol-1-yl)-5-chloro-phenol | HCID 117729754 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 123427162 | HCID 123427162 | 94.7% |
Reaction Steps
A solution of Intermediate 62b (615 mg, 2.31 mmol) and imidazole (189 mg, 2.78 mmol) in DMF (4.5 mL) was added tert-butyl dimethylchlorosilane (384 mg, 2.55 mmol). The solution was stirred for 2 h then added tert-butyl dimethylchlorosilane (192 mg, 1.28 mmol). After 1.5 h, the solution was diluted with water and extracted with EtOAc. The combined organics were dried and concentrated in vacuo to give the title compound (831 mg, 94%). LCMS (Method 3): Rt 5.21 min, m/z 380 [MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09440974B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-2f4d3d90d9144de89b305a23caecbe51 |
| Source note | uspto-grants-2016_09 |