4-Methylpiperazine-1-carbothioamide → 3-[2-(4-Methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzoic acid

Participants

Reaction Steps

4-Methyl-piperazine-1-carbothioic acid amide (2.47 mmol) and 3-(2-Bromo-acetyl)-benzoic acid (2.47 mmol) were mixed in THF (12 mL). After stirring at room temperature for 5 minutes the mixture was heated to 80° C. for 2 hours. The mixture was then cooled to room temperature and filtered. The solid was washed with a small amount of diethylether and dried. m/z=304.1 in MS ES+, which was characterized by hplc and MS and used in the next step without any further purification.

Provenance & Evidence