反应详情

Isothiocyanato-cyclopentane (4 g) in ammonia (37% in water, 8 mL) and methanol (32 mL) was stirred for 16 hours, filtered of and dried. The Cyclopentyl-thiourea (2.06 mmol) and 4-(2-Bromo-acetyl)-benzoic acid (2.06 mmol) were mixed in THF (12 mL). After stirring at room temperature for 5 minutes the mixture was heated to 80° C. for 2 hours. The mixture was then cooled to room temperature and filtered. The solid was washed with a small amount of diethylether and dried. m/z=289.05 in MS ES+, which was characterized by hplc and MS and used in the next step without any further purification.

1. filtrationfiltered of and
2. customdried
3. temperaturewas heated to 80° C. for 2 hours
4. temperatureThe mixture was then cooled to room temperature
5. filtrationfiltered
6. washThe solid was washed with a small amount of diethylether
7. customdried
8. customused in the next step without any further purification