反应详情

温度

2 °C

A 100 ml round bottomed flask equipped with a magnetic stir bar was charged with acetone (50 ml). Pantoprazole (10 g, 25.7 mmol) was then added to the flask. After the pantoprazole had completely dissolved, the solution was cooled to about 2° C. Forty seven percent sodium hydroxide (aq.) equivalent to 2.4 grams of solid sodium hydroxide (60.0 mmol) was slowly added to the cooled solution. A precipitate began to form immediately. The mixture was stirred for another two hours while the flask was allowed to warm to room temperature. The precipitate was filtered and washed with acetone (20 ml) and dried at 40° C. under vacuum to yield pantoprazole sodium Form II (6.9 g, 65%).

1. customA 100 ml round bottomed flask equipped with a magnetic stir bar
2. customto form immediately
3. temperatureto warm to room temperature
4. filtrationThe precipitate was filtered
5. washwashed with acetone (20 ml)
6. customdried at 40° C. under vacuum