Sodium Hydroxide → HCID 178493213, compound

HRID 606707Notes

Reaction equation

HRID 606707 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][N:6]=[C:7]([CH2:11][S+:12]([O-:26])[C:13]2[NH:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH:23]([F:25])[F:24])=[CH:19][C:20]=3[N:21]=2)[C:8]=1[O:9][CH3:10].[OH-].[Na+:28]>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][N:6]=[C:7]([CH2:11][S+:12]([O-:26])[C:13]2[N-:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH:23]([F:24])[F:25])=[CH:19][C:20]=3[N:21]=2)[C:8]=1[O:9][CH3:10].[Na+:28]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178493214Pantoprazole

Product 1

HCID 178493213HCID 178493213, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A 100 ml flask was charged with toluene (50.0 ml). Pantoprazole (5.0 g, 12.8 mmol) and 47% aqueous NaOH (1.2 g) were added to the stirred solvent at room temperature. The mixture was stirred until dissolution and then overnight until precipitation. The solid was filtered giving pantoprazole sodium. The sample was dried at 45° C. under 10 mm Hg vacuum overnight, giving 4.21 g of amorphous pantoprazole sodium.

Workup

  1. customovernight until precipitation
  2. filtrationThe solid was filtered

Sources & evidence

ORD record
ord-24d28905f6e740c4a9e934f355ac8919
Source dataset
uspto-grants-2011_03
Patent number
US07915423B2

Reaction notes

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