HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Nitrobenzenesulfonyl chloride → (2S,4S)-4-fluoro-1-[2-[(2-nitrophenyl)sulfonyloxy]acetyl]pyrro lidine-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Nitrobenzenesulfonyl chloride | HCID 15540 | — |
| Reactant | (2S,4S)-4-fluoro-1-(2-hydroxyacetyl)pyrrolidine-2-carbonitrile | HCID 67053346 | — |
| Product | (2S,4S)-4-fluoro-1-[2-[(2-nitrophenyl)sulfonyloxy]acetyl]pyrro lidine-2-carbonitrile | HCID 86627919 | 15.1% |
Reaction Steps
Using (2S,4S)-4-fluoro-1-(2-hydroxyacetyl)pyrrolidine-2-carbonitrile (259 mg) and 2-nitrobenzenesulfonyl chloride (366 mg), the same procedure was followed as in Reference Example 3 to give (2S,4S)-4-fluoro-1-[2-[(2-nitrophenyl)sulfonyloxy]acetyl]pyrro lidine-2-carbonitrile as a pale yellow solid (81.2 mg, 15% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07915427B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-7a2f95d21fa941968f5a662a205dc2da |
| Source note | uspto-grants-2011_03 |