(2S,4S)-1-[2-(benzenesulfonyloxy)acetyl]-4-fluoropyrrolidine-2-carbonitrile → Bisegliptin

Participants

Reaction Steps

Using ethyl 4-aminobicyclo[2.2.2]octane-1-carboxylate benzenesulfonate (609 mg) and (2S,4S)-4-fluoro-1-[2-(benzenesulfonyloxy)acetyl]pyrrolidine-2-carbonitrile (783 mg), the same procedure was followed as in Example 7 to give (2S,4S)-1-[2-[(4-ethoxycarbonylbicyclo[2.2.2]oct-1-yl)amino]ac etyl]-4-fluoropyrrolidine-2-carbonitrile (609 mg, 87% yield). This compound was identical to the compound obtained in Example 7.

Provenance & Evidence