Potassium Iodide → Bisegliptin

Participants

Reaction Steps

Using ethyl 4-aminobicyclo[2.2.2]octane-1-carboxylate trifluoroacetate (685 mg), (2S,4S)-4-fluoro-1-[2-(benzenesulfonyloxy)acetyl]pyrrolidine-2-carbonitrile (625 mg) and potassium iodide (33.2 mg), the same procedure was followed as in Example 7 to give (2S,4S)-1-[2-[(4-ethoxycarbonylbicyclo[2.2.2]oct-1-yl)amino]ac etyl]-4-fluoropyrrolidine-2-carbonitrile (511 mg, 73% yield). This compound was identical to the compound obtained in Example 7.

Provenance & Evidence