HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 606791Generated: October 30, 2026
Potassium Carbonate → 1-Chloro-3-ethynylbenzene
https://huagongshe.com/reaction/606791
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 18-Crown-6 | HCID 28557 | — |
| Reactant | 4-(3-Chlorophenyl)-2-methyl-3-butyn-2-ol | HCID 23006374 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-Chloro-3-ethynylbenzene | HCID 123086 | 66.2% |
Reaction Steps
Add dry toluene to a degassed mixture of 4-(3-chlorophenyl)-2-methylbut-3-yn-2-ol (21.1 g, 0.109 mol), potassium carbonate (45 g, 0.326 mol) and 18-crown-6 (6.89 g, 0.026 mol). Stir at 90° C. for 36 h. Cool the reaction mixture to room temperature, filter and wash with toluene. Concentrate and purify the residue by silica gel chromatography, eluting with 18:1 o 13:1 hexanes:ethyl acetate, to give the title compound (9.85 g, 66%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07915424B2 |
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| Source dataset | uspto-grants-2011_03 |
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| ORD ID | ord-b46969bcf8b0465daccdc5e39da688a3 |
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| Source note | uspto-grants-2011_03 |
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