HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → 5-(3-Fluorophenylethynyl)-pyridine-3-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Diisobutylaluminumhydride | HCID 21225700 | — |
| Reactant | 5-(3-Fluorophenylethynyl)-N-methoxy-N-methylnicotinamide | HCID 86622467 | — |
| Product | 5-(3-Fluorophenylethynyl)-pyridine-3-carbaldehyde | HCID 86076454 | 64% |
Reaction Steps
Prepare essentially as described in EXAMPLE 5 using a 1 M solution of diisobutylaluminum hydride in toluene (1.2 mL, 1.20 mmol), 5-(3-fluorophenylethynyl)-N-methoxy-N-methylnicotinamide, (prepared as described in PREPARATION 18), (170 mg, 0.60 mmol) to give the title compound (86 mg, 64%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07915424B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-933f2c4ff71343acbf7a0789cfff2a80 |
| Source note | uspto-grants-2011_03 |